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Novel antiviral agent based on modified chitosan
keywords: antiviral agent, chitosan, coronaviruses, respiratory tract infections in humans, biochemistry, biophysics, biotechnology
offer number: 152

Novel antiviral agent based on modified chitosan

  • Medical background: Coronaviruses (CoV) cause many diseases in humans and animals; in particular, human pathogens include HCoV-229E, HCoV-NL63, HCoV-OC43, HCoV-HKU1 and SARS-CoV. The latter causes a condition called Severe Acute Respiratory Syndrome (SARS) – an atypical pneumonia that first appeared in China in 2002. Until now, no effective cure for SARS has been introduced into the clinic, and the treatment of that disease is merely symptomatic. Viruses of this group are also responsible for serious diseases in animals. This fact is important not only in terms of the risk of transmission into human population (the SARS case), but also – in the case of farming animals – for economic reasons.
  • Potential antiviral agent: modified natural polysaccharides (chitosan polymer)
  • Key features:
    • Development stage: preclinical phase.
    • IP status: several international patent application: EPO, USA, Canada, Japan, China, India (November, 2014).
    • Confirmed ability to efficient bind of coronaviruses and inhibit their replication in vitro and/or ex vivo.
    • Modified chitosan has antibacterial and antifungal activity, which is
      an additional advantage of the offered polymer.
    • The possibility to apply as a solution or spray administrated either topically to the upper respiratory tract (throat, nose, bronchial tree), orally in the case of gastrointestinal infections or intravenously for systemic therapy.
commercial utility: treatment and prevention of viral infections caused by coronaviruses in humans, including respiratory diseases manifested by impaired respiratory function.
field of science: biochemistry, biophysics, biology, medical biology, medicine, microbiology, pharmaceutical science, health sciences, biotechnology
forms of protection: patent application
technological maturity: demanding R & D
property rights: Jagiellonian University
variants of cooperation: license, consulting, spin-off company, comercial contract research, sale

information / broker of Jagiellonian University

name and surname: Klaudia Polakowska, PhD
phone number: +48 12 664 42 13, +48 519 329 129
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