SPION – superparamagnetic iron oxide nanoparticles covered with ultrathin polymer layers.
New opportunities of MR imaging
Magnetic Resonance Imaging, MRI, is one of the most advanced tomography techniques used in medical diagnostics. The method allows for obtaining in nonivasive way the cross-section of the patient's body and it is widely used inter alia in neurology and cancer diagnostics. In order to improve performance of obtained MRI image and to reveal the structures of less clear visibility, including blood vessels, and inflammatory foci and the tumors, the contrast agents are typically used. The most commonly used agents are composed of gadolinium ions complexes, which due to their toxicity carry the risk of complications and require a relatively rapid removal from the patient’s body. The offered superparamagnetic iron oxide nanoparticles (SPION), whose magnetic properties can produce a good effect at much lower doses than commonly used agents, can serve as interesting alternative.
SPION – innovative solution
The main advantages of the offered contrast agent for MRI based on modified superparamagnetic iron oxide nanoparticles are:
- slight size variability,
- sustained and controlled surface charge,
- high magnetic relaxivity,
- considerably better magnetic properties of the material than in these of commercially available contrast agents,
- high stability of dispersion in aqueous suspension.
An important advantage of the offer is also a method for the synthesis of nanoparticles. This process takes place in an aqueous medium, and is carried out without organic solvents, the toxic precursors and difficult to remove surfactants. The modification of the polymer coatings surrounding the iron oxide nanoparticles, allowing for their use in diagnostics by fluorescence microscopy techniques, is also possible.
SPION is the subject of patent application. Further development of the invention is carried out by scientists from Faculty of Chemistry, JagiellonianUniversity and Jagiellonian Centre for Experimental Therapeutics (JCET).
Currently the Centre for Technology Transfer CITTRU is looking for the entities interested in the cooperation and commercial applications of the described solution, especially in the acquisition of a license for the described materials and their applications.
CITTRU is also searching for the business partners for joint research and development projects involving the above materils.
diagnostic techniques based on nuclear magnetic resonance and fluorescence microscopy