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Departament of Clinical Pharmacy Faculty of Pharmacy Jagiellonian University CM
keywords: pharmacy, clinical, epilepsy, psychiatric
offer number: 87
research topics:
  • study of pharmacological properties of centrally acting molecules with potential application in treatment of psychiatric  diseases, neurodegenerative disorders and epilepsy, and as pain relievers,
  • pharmacological properties (in vitro and in vivo tests) of newly synthesized compounds based on molecular mechanism of ligand-receptor interaction are specified in the frame of wide structure-affinity and structure-activity relationships studies (mainly behavioral tests on rodents).
test equipment:
  • HPLC Waters Alliance 2695 Separation Module,
  • Tail suspension stations for automatic assay (Campden Instruments Ltd.),
  • Aron Apparatus (Bioseb),
  • Elevated Plus - maze station for rats (Campden Instruments Ltd.),
  • Motor monitor automatic system for rats (Campden Instruments Ltd.),
  • Vogel Test System for rats (TSE),
  • Opto-M3 Dual Axis 20 Cage System with 8 inch X axis sensors and 4 inch Y axis sensors for mice (Columbus Instruments),
  • Hot plate analgesia for mice and rats (COMMAT LTD.),
  • Elektroshoker generator for mice and rats (ugo basile s.r.l),
  • Catalepsy - bar test for mice and rats,.

 

Methods and research techniques:

  • mouse locomotor activity test  - Opto-M3 – 20 Cage system with inch X axis sensors and inch Y sensors for mice,
  • the study of exploratory activity in rats - an automatic monitoring system,
  • anticonvulsant activity - shock generator for mice and rats,
  • the analgesic activity - hot plate in mice and rats,
  • anxiolytic activity:
    • Vogel Test System for Rats, Elevated Plus-maze test for rats,
    • The antidepressant activity - studying the behavior of mice and rats in the forced swim test and the tail suspension,
  • the behavior of mice and rats in the catalepsy test - a test rod.
comercial research:
  • search for new psychotropic compounds e.g. selective ligands of receptors located in the central nervous system (as a tool for pharmacological studies) and/or compounds with multireceptor mechanism of action (as new drugs),
  • behavioural study in rodents (mice, rats, guinea-pigs) of new compounds as potential:  antidepressants, anxiolytics, antipsychotics, antiepileptics, cognitive drugs, local and central acting analgetics. 
experience / references / projects:
  • collaboration with the pharmaceutical company Adamed,  the project: "Development of an innovative drug used in the treatment of central nervous system diseases: schizophrenia, depression and anxiety, preclinical studies." 
  • behavioural study in rodents (mice, rats, guinea-pigs) of new compounds as potential:  antidepressants, anxiolytics, antipsychotics, antiepileptics, cognitive drugs, local and central acting analgetics.
variants of cooperation: contract research, project, consortium
type of services: analysis, devices for rent, expertises

information / broker of Jagiellonian University

name and surname:
phone number: + 48 12 664 42 00
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