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Chair and Department of Pharmaceutical Chemistry Faculty of Pharmacy Jagiellonian University
keywords: chemistry, pharmaceuticak chemistry, chemistry of heterocyclic compounds, synthesis, molecular modeling
offer number: 75
research topics:

Drug chemistry:

  • Design and synthesis of selective and multi-receptor 5-HT1A, 5-HT2A, 5-HT6, 5-HT7, D2 with potential antidepressant, antipsychotic and anxiolytic activity
  • Design and synthesis of selective 5-HT6 ligands with precognitive activity
  • Design and synthesis of compounds active in different animal models of epilepsy, as potential wide range anticonvulsants

Chemistry:

  • Chemistry of heterocyclic compounds
  • Microwave supported synthesis
  • Synthesis on solid support

Analyses:

  • Molecular modeling: GPCR homology models, ligand docking, scanning of databases based on homology models
  • Assignment of compound’s structure (spectroscopic methods, mass spectrometry, elemental analysis)
test equipment:
  • HPLC Waters 2695 Separation Module
  • UPLC/MS Waters ACQUITY™ TQD system
  • Vario EI III Elemental analyser
  • UV Lambda 12 Perkin Elmer Spectrometer
comercial research:
  • Design and synthesis of on new compounds acting on central nervous system, particularly with potential antidepressant, antipsychotic, anxiolytic and anticonvulsant activity
  • Synthesis of building block for external customers
  • Assignment of compound’s structure (spectroscopic methods, mass spectrometry, elemental analysis)
  • Synthesis pathway design and optimization based on the synthesis in solution and on the solid support for external customers
  • Optimization of synthesis paths
  • Analysis of by-products (identification of impurities)
  • LC/MS, LC/MS/MS analysis (UPLC/MS Waters ACQUITY™ TQD system)
  • Elemental analysis

Methods and research techniques:

  • Synthesis in solution
  • Synthesis on solid support
  • Microwave supported synthesis
  • High performance liquid chromatography (HPLC)
  • Mass spectrometry (LC/MS, LC/MS/MS)
  • Elemental analysis
experience / references / projects: Project entitled: ’The search of new, innovative psychotropic drug’. The studies realized in co-operation with Adamed Sp. z o.o. pharmaceutical company (Pieńków) and Institute of Psychiatry and Neurology (Warszawa)
variants of cooperation: contract research, project, consortium
type of services: analysis, devices for rent, expertises

information / broker of Jagiellonian University

name and surname:
phone number: + 48 12 664 42 00
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