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Department of Pharmacokinetics and Physical Pharmacy, Faculty of Pharmacy Jagiellonian University CM
keywords: statistical analysis, pharmacokinetic, analytical methods
offer number: 88
research topics:
  • pharmacokinetic and pharmacokinetic-pharmacodynamic studies on new compounds;
  • assessment of pharmacokinetic drug interactions involving metabolism, drug transport and plasma protein binding;
  • investigation on the influence of some inflammatory disorders on pharmacokinetic profile of drugs in experimental disease models;
  • application of population modeling to optimization of pharmacotherapy;
  • application of  pharmacokinetic-pharmacodynamic modeling to data analysis and simulations;
test equipment:
  • HPLC with DAD, electrochemical and fluorimetric detection (Merck Hitachi, 2007, Japan)
  • organ perfusion system PS-1 (Hugo Sachs Elektronik - Harvard Apparatus, 2009, United Kingdom)
  • microdialysis system (CMA Microdialysis AB, 1999, Sweden)
  • Equilibrium dialysis system (Harvard Apparatus, 2011, United Kingdom)
  • Flow-through cell apparatus (Ismatec/Julabo , 2011, Germany) 
comercial research:
  • development and validation of analytical methods  for determination of new compounds in   different biological matrices (plasma, serum, urine, tissue homogenates);
  • assessment of pharmacokinetic profiles of new compounds and selection of compounds with the most favourable pharmacokinetic parameters for further development;
  • assessment of plasma protein binding  of new compounds;
  • evaluation of metabolism and transport of new compounds using isolated perfused organs;
  • selection of an appropriate dose for phase I clinical trials (allometric scaling);
  • measurement of markers of drug response and assessment of pharmacokinetic-pharmacodynamic relationships;
  • pharmacokinetic studies on new compounds – drug candidates performed according to FDA and EMA recommendations;
  • development and validation of analytical methods for determination of compounds in different biological matrices (serum, plasma, tissue homogenates, urine, feces) using HPLC with different types of detection according to FDA and ICH recommendations;
  •  Development and validation of enantioselective HPLC methods for racemic compounds;
  • determination of biomarkers of drug response and pharmacokinetic-pharmacodynamic modelling;
  • statistical analysis;
variants of cooperation: contract research, project, consortium
type of services: analysis, devices for rent, expertises

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