The group focuses on harnessing the therapeutic potential of stem cells and extracellular vesicles in gene therapy and regenerative medicine.

Group Leader – PhD Sylwia Bobis-Wozowicz

https://zbk.wbbib.uj.edu.pl/en_GB/zespol/pracownicy/sylwia-bobis-wozowicz

https://cysticfibrosis.project.uj.edu.pl/en_GB/

• Drug delivery systems based on extracellular vesicles
• Genome editing (CRISPR/Cas9) and genetic modification of cells (electroporation, viral vectors)
• Cell reprogramming to a pluripotent state (fibroblasts, blood cells from patients and healthy donors)

We are a group of enthusiastic scientists and students united by a passion for discovering innovative solutions in the field of human health. Our research priority is to explore novel strategies in regenerative medicine and gene therapy. By leveraging our knowledge, experience, and scientific curiosity, we consistently strive to achieve ambitious goals. What motivates us is the opportunity to transform research findings into breakthrough therapies that can improve patients’ quality of life.

The group is currently implementing an applied research project entitled “Innovative Treatment Strategy for Cystic Fibrosis” (First Team FENG.02.02-IP.05-0064/23), whose overarching goal is to develop a novel therapy for cystic fibrosis using advanced technologies based on extracellular vesicles and genome editing tools (CRISPR/Cas9).

Using in vitro cell models and in vivo studies on experimental animals, the effectiveness of achieving gene correction and inhibiting multi-organ fibrosis (in the lungs and intestines) will be evaluated. This fibrosis develops during the course of the disease and may lead to complete organ dysfunction.