research topics:

Drug chemistry:

• Design and synthesis of selective and multi-receptor 5-HT_1A, 5-HT_2A, 5-HT₆, 5-HT₇, D₂ with potential antidepressant, antipsychotic and anxiolytic activity
• Design and synthesis of selective 5-HT₆ ligands with precognitive activity
• Design and synthesis of compounds active in different animal models of epilepsy, as potential wide range anticonvulsants

Chemistry:

• Chemistry of heterocyclic compounds
• Microwave supported synthesis
• Synthesis on solid support

Analyses:

• Molecular modeling: GPCR homology models, ligand docking, scanning of databases based on homology models
• Assignment of compound’s structure (spectroscopic methods, mass spectrometry, elemental analysis)

test equipment:

• HPLC Waters 2695 Separation Module
• UPLC/MS Waters ACQUITY™ TQD system
• Vario EI III Elemental analyser
• UV Lambda 12 Perkin Elmer Spectrometer

comercial research:

• Design and synthesis of on new compounds acting on central nervous system, particularly with potential antidepressant, antipsychotic, anxiolytic and anticonvulsant activity
• Synthesis of building block for external customers
• Assignment of compound’s structure (spectroscopic methods, mass spectrometry, elemental analysis)
• Synthesis pathway design and optimization based on the synthesis in solution and on the solid support for external customers
• Optimization of synthesis paths
• Analysis of by-products (identification of impurities)
• LC/MS, LC/MS/MS analysis (UPLC/MS Waters ACQUITY™ TQD system)
• Elemental analysis

Methods and research techniques:

• Synthesis in solution
• Synthesis on solid support
• Microwave supported synthesis
• High performance liquid chromatography (HPLC)
• Mass spectrometry (LC/MS, LC/MS/MS)
• Elemental analysis

experience / references / projects: Project entitled: ’The search of new, innovative psychotropic drug’. The studies realized in co-operation with Adamed Sp. z o.o. pharmaceutical company (Pieńków) and Institute of Psychiatry and Neurology (Warszawa)

variants of cooperation: contract research, project, consortium

type of services: analysis, devices for rent, expertises